The usage of biopesticides dates back to the 1950s and they are made from live creatures like bacteria or plants. For instance, Bacillus thuringiensis, a Gram-positive bacterium, has been employed extensively as an insecticide since that time and does so by producing crystal proteins. When these proteins are consumed, the alkaline digestive system of insects converts the insoluble crystal proteins into a soluble form, enabling them to proceed through proteolysis by gut enzymes. The localized digestive tract damage caused by the released poison usually results in the insect starving to death. Since then, crops have been genetically modified to produce the crystal protein gene, giving them some resistance to insect pests. The lack of receptors in humans and the majority of non-target insects render the crops safe for food and may prevent the use of more hazardous and environmentally harmful chemical pesticides.

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